Human cells from different organs are placed on the chips and supplied with a nutrient solution via small channels. In this way, blood circulation and metabolic functions of the human body are simulated. Monitoring after the addition of active substances such as drugs, cosmetics, or chemicals allows conclusions to be drawn about the reactions and processes in the human body.
The continuous supply of the cells with a liquid nutrient medium is a great challenge, as even small variations influence the test results. The LiquiDoS dosing system by HNP Mikrosysteme contains a highly precise, low-shear micro annular gear pump (mzr pump), which is ideally suited for filling the biochip. Volume flows from 1.5 µl/min to 72 ml/min as well as dosing volumes from 0.25 µl are gently realized with the LiquiDoS. In addition to the micropump, LiquiDoS contains a filter, a shut-off valve, and the mzr-Touch Control. The graphical user interface facilitates the handling of the system by direct input of dosing quantity and dosing duration. Furthermore, the mzr-Touch Control enables simple programming, fast switching between manual and automated dosing tasks as well as reproducible results.
