Fluid Handling Technology News & Innovations
Pharmaceutical manufacturing has extremely precise requirements and manufacturing guidelines in terms of quality. Therefore, all pharmaceutical manufacturing technology must comply with all required internationally relevant legal, quality, and safety standards. After all, health cannot be compromised. Products are made in larger quantities and this affects the cleaning of the equipment used.
Pharmaceutical Technology can be defined as all technologies related to the development (including analysis, test, research and development, and quality control) of a pharmaceutical form using natural, semi-synthetic and synthetic active and auxiliary substances, and the industrial production.
Pharmaceutical technology includes methods, techniques, and instrumentation in the manufacture, preparation, compounding, dispensing, packaging, and storing of drugs and other preparations used in diagnostic and determinative procedures and the treatment of patients.
Pharmaceutical manufacturing is the process of industrial-scale development of pharmaceutical drugs by pharmaceutical companies. The process of pharmaceutical manufacturing can be broken down into a series of unit operations.
Both the sterile and nonsterile pharmaceutical manufacturing process needs to be designed and operated for that microbial contamination are minimized. Good design practices require an assessment of hazards and a calculation of risks, together with risk mitigation strategies.
A correct risk assessed process can be achieved through a purposefully designed monitoring regime. The scope of such assessments needs to begin with supplier assessments and control of incoming raw materials through to distribution of the manufactured pharmaceutical product.
Pharmaceutical fluid handling equipment includes a wide variety of equipment, such as (metering) pumps, capsule equipment (filling, sorting), mixing equipment, thermal processing equipment (coolers, chillers, dryers, heat-exchangers), (x-ray) inspection systems, and tanks for holding liquids.
To guarantee precise manufacturing and formulation development, nearly every process can be automated. Resultantly, there is a piece of pharmaceutical manufacturing equipment involved in every processing step.
Product integrity is crucial in the pharmaceutical industry. For a product to maintain the same characteristics in every production batch, the highest sanitation standards must be observed.
In pharmaceutical processing industries, measuring and controlling the flow of liquids and gases demands exceptional process instrument performance and networkability.
Production of pharmaceutical liquids is carried out in temperature-controlled stainless-steel tanks with stirring units under the addition of chemicals with or without nutrient solutions.
A full understanding of the pharmaceutical production process is the key concept for the correct design. Clear definition, assessment, monitoring of critical parameters directly affecting product quality are the baseline for the application of suitable process systems granting both complete in-line and at-line quality control.
The vast majority of liquid pharmaceutical solutions require a variety of tankage, piping, and ancillary equipment for liquid mixing, filtration, transfer, and related activities. Suspensions, ointments, and other similar products, including the preparation of the solutions for freeze-dried products, can be manufactured in the same or very similar equipment.
Commercial liquid dosage manufacturing reaches large - scale production after being preformulated at the laboratory level, followed by formulation at the small scale and then at the pilot plant scale.
Due to the complexity of the liquid dose manufacturing process, scale-up from pilot to commercial production is not a simple extrapolation.
The major ingredient in most liquid dose manufacturing process is water. While it is the safest and most palatable solvent option, water quality is significant for the stability of pharmaceutical dosage forms.
Liquid pharmaceutical dosage forms are essentially pharmaceutical products in the form that involves a mixture of active drug components and nondrug components (excipients).
Liquid pharmaceutical dosage forms are prepared:
Sterile liquids manufacturing is universally acknowledged to be the most difficult pharmaceutical production process.
When these products are manufactured using aseptic processing, poorly controlled processes can expose the patient to an unacceptable level of contamination.
The production of sterile liquid products requires fastidious design, operation, and maintenance of facilities and equipment.
It also requires attention to detail in process development and validation to ensure success.
Sterile liquids manufacturing is heavily impacted both by formulation and the selection of primary packaging components.
The pharmaceutical processing industry is under constant pressure to increase efficiency, reduce costs, and maintain quality.
Forward-thinking pharmaceutical processing companies have invested in smarter manufacturing and are considering a move to a continuous manufacturing process.
The goals are clear, build in regulatory compliance, ensure close monitoring of processes, de-risk the manufacturing chain and enable fast drug release.
In pharmaceutical technology, the market has been increasing the level of standardization in high added value equipment for years. Examples of this trend are autoclaves, freeze dryers, filling lines, distillers, etc.
However, when it comes to process equipment for preparing, storing and transferring liquid pharmaceuticals, no studies of needs and applications exist to date at the level of both engineering and pharmaceutical technology.
Amidst the ongoing Sars-CoV-2 coronavirus pandemic, laboratories around the globe are working tirelessly to find a vaccine. Yet, with the health and lives of people all over the world at stake, time is running out.
Read moreInternational Active Pharmaceutical Ingredients (API) manufacturing company with plants based in the Republic of Ireland were having problems with Tubular Diaphragm Pumps.
Read moreThe requirements placed on the service life, reliability and functionality of applied valves in process technology – especially in the pharmaceutical and food industries – are increasing all the time. Bürkert Fluid Control Systems has taken on this challenge and invested in a multi-medium testing facility.
Read moreMost suppliers are content to meet the customer’s specifications. Not us. At Trelleborg, we try to exceed expectations.
Read moreThe new DFI (Diaphragm Failure Indication) technology offers enhanced protection through a duplex diaphragm and an integrated permanent diaphragm monitoring with automatic failure alarm. DFI is available with both a pressure transmitter and a pressure gauge.
Read moreCrossflow filtration (also called tangential flow filtration) is a separation or purification technique which is often used in the (bio)pharmaceutical industry and relies on the feed flow travelling across the surface of a membrane as opposed to dead-end filtration, in which the feed is led through a membrane.
Read moreWatson-Marlow Fluid Technology Group (WMFTG) has launched BioPure silicone transfer tubing to provide a safe, reliable and value-based solution for a wide range of bioprocess fluid transfer applications.
Read moreCutting edge diagnosis and genomic equipment depends on high accuracy and speed to deliver results. Operating with micro quantities of fluid in this context presents a significant challenge – which has now been overcome, thanks to Bürkert’s new pressure controller, the Type 8763. Designed specifically for time-pressure dosing applications, this latest product delivers a host of benefits for manufacturers of pharmaceutical and medical diagnosis equipment.
Read moreWhen attempting to describe the processes that are inherent to biopharmaceutical manufacturing, words like “complex,” “precise” and “pure” come to mind most often.
Read moreTitan Enterprises reports that its Atrato and MetraFlow ultrasonic inline flowmeters are used by drug manufacturers to streamline production and reduce costs.
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Siemens solutions increases efficiency and enhances quality. Our instruments for flow, level, pressure and temperature, provides data to optimize your process, reduce energy usage and ensure safety.
The Young Calibration laboratory provides UKAS accredited calibration (Laboratory 0604) services and thermal fluid and component testing services to a wide scope of industries.
ValvTechnologies is the leading manufacturer of zero leakage, severe service isolation valve solutions for the fossil power, nuclear generation, oil & gas, heavy oil, refining, petrochemical, mining and minerals, pulp and paper sectors.
Equflow has perfected the flow measurement of liquids. The technology company has further developed its own invention into commercial solutions for various applications in which flow measurement is crucial.
Verder Liquids manufactures pumps, mixers and systems. Verder pumps are able to transfer all kinds of liquids in many industries such as chemical industry, process industry food pharmaceutical industry and water treatment.
Vögtlin is a Swiss developer of precision digital mass flow meters & controllers for gases serving a wide range of applications: Life Science, Biotech, OEM and many more.
Titan Enterprises are a leading manufacturer of high-performance products including the Atrato ultrasonic flowmeter, Oval Gear flowmeters, low flow Turbine flow meters and a flow instrument range.
FLEXIM, known as the technology and market leader in the field of clamp-on ultrasonic flowmeters and real time concentration and density monitoring as well as advanced process analytics using clamp-on ultrasound and inline refractometry.
